Why is Spyre Therapeutics, Inc. stock down today?

September 23, 2026

Spyre Therapeutics, Inc.

SYRE · NMS · USD

$86.86

▼ 5.11 (5.56%)

vs. prev. close $91.97

Last updated Sep 23, 2026 16:20

Intraday Chart — 5-min intervals

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AI Summary

SYRE · less than a minute ago

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Spyre Therapeutics, Inc. trades lower by 5.56% with investors watching Simply Wall St.

The stock is at $86.86, a 5.56% move down versus the prior close of $91.97. Two headlines stand out today: "What Does Spyre Therapeutics (SYRE) Part A Trial Success Mean For Ulcerative Colitis?" and "Psoriatic Arthritis Market Landscape: 6 Key Late-Stage Drugs Set to Drive Future Growth | DelveInsight". Taken together, the news tone looks mixed.

Market context matters here: S&P 500: -0.7%, Nasdaq: -1.1%, Dow Jones: -0.6%, Shanghai: -0.3%, Hang Seng: -0.8%, leaving the overall tape under pressure.

Use this as a starting point for research, not as a trading recommendation.

Key Factors

1Simply Wall St.: What Does Spyre Therapeutics (SYRE) Part A Trial Success Mean For Ulcerative Colitis?

2GlobeNewswire: Psoriatic Arthritis Market Landscape: 6 Key Late-Stage Drugs Set to Drive Future Growth | DelveInsight

3Insider Monkey: Spyre (SYRE) Clears Monotherapy Phase for IBD Portfolio, Setting Up Combination Tests

4Broad market: S&P 500: -0.7%, Nasdaq: -1.1%, Dow Jones: -0.6%, Shanghai: -0.3%, Hang Seng: -0.8%

Auto-generated analysis · Not financial advice

less than a minute ago

📰Recent News

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⚠️ Disclaimer: The information on this page is for informational purposes only and does not constitute financial advice. AI-generated summaries may be inaccurate. Always conduct your own research and consult a licensed financial advisor before making any investment decisions. Past performance is not indicative of future results.

🌐Market ContextRisk-Off 📉

S&P 500

-0.67%

Nasdaq

-1.07%

Dow Jones

-0.63%

Shanghai

-0.34%

Hang Seng

-0.83%

Nikkei 225

+1.38%

FTSE 100

-0.03%

Nifty 50

+0.14%

DAX

-0.66%

OMX Stockholm

-0.57%

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